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Saturday, November 21, 2009 9:51 PM

Polymerase

Type: Keyphrase

Name: Polymerase

First Reported 11/19/2009 - Updated 11/19/2009 - 1 Documents (in Health)

Analysis reveals two genetic clusters of H1N1 viruses

Analysis of all complete genome sequences of the pandemic influenza A(H1N1)v virus available as of 10 September 2009 revealed that two closely related but distinct clusters were circulating in most of the affected countries at the same time. The characteristic ... [Eurosurveillance - 11/19/2009]

Entities: Virus, Influenza A H1N1 Virus, Protein, Nucleotide

First Reported 11 hours ago - Updated 11 hours ago - 1 Documents (in Chemistry)

An experimental loop design for the detection of constitutional chromosomal aberrations by array CGH.

ABSTRACT: BACKGROUND: Polyhydroxyalkanoates (PHA) are synthesized by many bacteria in the cytoplasm as storage compounds for energy and carbon. The key enzymes for PHA biosynthesis are PHA polymerases, which catalyze the covalent linkage of 3-hydroxy ... [Bioscience Technology Online - 11 hours ago]

Entities: Cytoplasm, Polymerase, Enzyme, Bacteria

First Reported 11 hours ago - Updated 11 hours ago - 1 Documents (in Biotechnology)

Expression profiling of rainbow trout testis development identifies evolutionary conserved genes involved in spermatogenesis.

Entities: Spermatogenesis, Conserved, Cytoplasm, Polymerase

First Reported 11 hours ago - Updated 11 hours ago - 1 Documents (in Health)

Prediction of protein binding sites in protein structures using hidden Markov support vector machine.

Entities: Protein, Vector, Cytoplasm, Polymerase

First Reported 11/18/2009 - Updated 11/18/2009 - 1 Documents (in Medicine)

Glitch in InterMune's HCV Trial; Toxicity Worries Cut High Dose

Eyes Still on Pirfenidone in IPF By Jennifer Boggs Assistant Managing EditorInterMune Inc. dipped on news that it would stop testing the highest dose in its ongoing Phase IIb study of protease inhibitor ITMN-191 in hepatitis C virus after reports of liver ... [BioWorld - 11/18/2009]

Entities: InterMune Incorporated, pirfenidone, Toxicity, Bayko, Antiviral

First Reported 11/18/2009 - Updated 11/18/2009 - 1 Documents (in Health)

Oral HCV Protease Inhibitor R7227 plus Polymerase Inhibitor R7128 Suppresses HCV Viral Load without Interferon or Ribavirin

SUMMARY: Combination hepatitis C treatment using the nucleoside analog hepatitis C virus (HCV) polymerase inhibitor RG7128 (formerly R7128) plus the HCV NS3/4A protease inhibitor RG7227 (formerly R7227, also known as ITMN-191) produced potent antiviral ... [HIV and Hepatitis.com - 11/18/2009]

Entities: Interferon, ribavirin, Polymerase

First Reported 11/18/2009 - Updated 11/18/2009 - 1 Documents (in Biology)

Convenient and Fast DNA Labelling

PromoKine’s DNA Labelling Kits have been designed for convenient fluorescent DNA labelling by PCR or nick translation using Taq polymerase or Polymerase I/DNase I. The fluorescently labelled dUTP analogs provided with the kits have been optimized for ... [Select Science - 11/18/2009]

Entities: DNA, Taq Polymerase, Nucleic Acid Hybridization

First Reported 11/02/2009 - Updated 11/03/2009 - 4 Documents (in Health)

INFORM-1 Results: Robust Antiviral Suppression Achieved with Combination of Nucleoside Analog Polymerase Inhibitor RG7128 and Protease Inhibitor RG722

BOSTON, Nov. 3 /PRNewswire-FirstCall/ -- InterMune, Inc. (Nasdaq: ITMN) and Pharmasset, Inc. (Nasdaq: VRUS) today announced results from all patient cohorts of the INFORM-1 trial, an innovative Phase 1 study of two direct-acting antiviral (DAA) compounds ... [Yahoo! Canada - 11/03/2009]

Entities: Nucleoside, Interferon, ribavirin

First Reported 11/04/2009 - Updated 11/05/2009 - 2 Documents

Combination Therapy With A Nucleoside Polymerase (RG7128) And Protease (RG7227/ITMN-191) Inhibitor In HCV: Safety, Pharmacokinetics, And Virologic Results From INFORM-1

Boston, MA EJ Gane, SK Roberts, CA Stedman, PW Angus, B Ritchie, R Elston, D Ipe, PN Morcos, I Najera, T Chu, MM Berrey, WZ Bradford, M Laughlin, NS Shulman, PF Smith Auckland Clinical Studies, Auckland, New Zealand; The Alfred, Melbourne, Australia: ... [National AIDS Treatment Advocacy Project - 11/05/2009]

Entities: ViroLogic Incorporated, Polymerase, Nucleoside, Protease, Pharmacokinetics

First Reported 10/27/2009 - Updated 10/28/2009 - 2 Documents (in Biology)

Ohio State University researchers, the first to observe real-time behavior of an enzyme called Dpo4

Scientists here have identified how the motions of an enzyme are related to correctly copying genetic instructions, setting the stage for studies that can uncover what happens when DNA copying mistakes are made.Perpetuation of DNA mistakes can cause mutations ... [News-Medical.Net - 10/28/2009]

Entities: Enzyme, DNA, Nucleotide, Polymerase

First Reported 11/05/2009 - Updated 11/05/2009 - 2 Documents (in Health)

Selective Eradication Of Malignant Cells

The ultimate goal in cancer research, a treatment that kills cancer cells whilst leaving healthy cells untouched, is brought nearer by the success of a new therapeutic approach. The potential therapy, published in BioMed Central's open access journal ... [Medical News Today - 11/05/2009]

Entities: Breast Cancer, malignant, BioMed Central, Polymerase, Proliferation

First Reported 11/03/2009 - Updated 11/03/2009 - 2 Documents

SCYNEXIS' SCY-635 Demonstrates Positive Antiviral Activity in Combination with Approved and Investigational Anti-HCV Agents

--In Vitro Results presented in a poster session at AASLD; Phase 2 combination studies to be initiated in 2Q 2010--Drug discovery company SCYNEXIS, Inc. today presented positive data from an in vitro study evaluating the antiviral activity of SCY-635 ... [FinanzNachrichten.de - 11/03/2009]

Entities: SCYNEXIS Inc, Antiviral, Polymerase, investigational

Quotes

...subtilis controls DnaA-mediated replication initiation but not the transcriptional response to replication stress' new findings in life sciences. "yabA encodes a negative regulator of replication initiation in Bacillus subtilis and homologues are found in many other gram-positive species. YabA interacts with the beta-processivity clamp (DnaN) of DNA polymerase and with the replication initiator and transcription factor DnaA" scientists writing in the journal Molecular Microbiology report

Life Sciences: Researchers at Massachusetts Institute of Technology, Department of Biology target ... [NewsRX - 11/10/2009]

...However, in the current research, breast cancer cells lacking the BRCA mutation were efficiently eradicated. According to Professor Cohen-Armon, "This research provides a new therapeutic approach for a selective eradication of abundant human cancers." Notes: A selective eradication of human non-hereditary breast cancer cells by phenanthridine derived polyADP-ribose polymerase inhibitors Dana Inbar...

Selective Eradication Of Malignant Cells [Medical News Today - 11/05/2009]

...and also allow for patients to be treated who are unable to take interferon based therapy," said Edward Gane, MD, lead investigator on this study. "The greater numbers treated and better success rates should eventually help reduce the future projected burden of end-stage liver disease for chronic HCV."

Study results of nucleoside polymerase and protease inhibitor combination therapy for HCV promising [News-Medical.Net - 11/04/2009]

(i) "Combination Therapy with a Nucleoside Polymerase (RG7128) and Protease (RG7227/ITMN-191) Inhibitor Combination in HCV: Safety, Pharmacokinetics, and Virologic Results from INFORM-1" Abstract #193: to be presented at the Meeting of the American Association for the StudyStudy of the Liver (AASLD) in Boston, Massachusetts, October 30...

INFORM-1 Results: Robust Antiviral Suppression Achieved with Combination of Nucleoside Analog Pol ... [Yahoo! Canada - 11/03/2009]

More Content

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Rhesus glycoprotein p2 (Rhp2) is a novel member... [Bioscience Technology Online - 11 hours ago]
Structure, affinity and availability of estroge... [Bioscience Technology Online - 11 hours ago]
Expression of TNF-related apoptosis-inducing li... [Bioscience Technology Online - 11 hours ago]
Nuclear protein kinases: still enigmatic compon... [Bioscience Technology Online - 11 hours ago]
Initial activation of EpCAM cleavage via cell-t... [Bioscience Technology Online - 11 hours ago]
Aortic valve stenotic area calculation from pha... [Bioscience Technology Online - 11 hours ago]
Xanthorrhizol, a Natural Sesquiterpenoid, Induc... [Bioscience Technology Online - 11 hours ago]
Research on key techniques of virtual reality a... [Bioscience Technology Online - 11 hours ago]
iNOS activity is necessary for the cytotoxic an... [Bioscience Technology Online - 11 hours ago]
Investigation into the controversial associatio... [Bioscience Technology Online - 11 hours ago]
The stress-inducible protein p8 is involved in ... [Bioscience Technology Online - 11 hours ago]
Imaging of Back Pain in Children. [Bioscience Technology Online - 11 hours ago]
Occupational and environmental hazard assessmen... [Bioscience Technology Online - 11 hours ago]
Development of a novel monoclonal antibody with... [Bioscience Technology Online - 11 hours ago]
Correction: Digital PCR provides sensitive and ... [Bioscience Technology Online - 11 hours ago]
A transcriptome analysis identifies molecular e... [Bioscience Technology Online - 11 hours ago]
Prediction of protein binding sites in protein ... [Bioscience Technology Online - 11 hours ago]
Expression profiling of rainbow trout testis de... [Bioscience Technology Online - 11 hours ago]
An experimental loop design for the detection o... [Bioscience Technology Online - 11 hours ago]
Studies conducted at Yamaguchi University on DN... [NewsRX - 11/20/2009]
Analysis reveals two genetic clusters of H1N1 v... [Eurosurveillance - 11/19/2009]
Research and Markets: Hepatitis C Virus and The... [Forbes.com - 11/19/2009]
Research and Markets: Hepatitis C Virus and The... [Business Wire - 11/19/2009]
Nobelmen: the secret behind DNA cloning [The Varsity Online - 11/19/2009]
Convenient and Fast DNA Labelling [Select Science - 11/18/2009]
Glitch in InterMune's HCV Trial; Toxicity Worri... [BioWorld - 11/18/2009]
Oral HCV Protease Inhibitor R7227 plus Polymera... [HIV and Hepatitis.com - 11/18/2009]
AACR-NCI-EORTC conference highlights major expa... [News-Medical.Net - 11/17/2009]
How Cells Tolerate DNA Damage - MDC Researchers... [MediLexicon - 11/16/2009]
How Cells Tolerate DNA Damage - MDC Researchers... [Medical News Today - 11/16/2009]

Blogs

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My two cents on the death penalty \| Michael Tom... [Comment is free \| guardian.co.uk - 11/12/2009] Predictably enough, some conservative commenters popped their corks over this morning's post about Hasan's right to legal counsel. For the record: I'm against the ...
New and Exciting in PLoS ONE [A Blog Around The... [ScienceBlogs : Combined Feed - 10/07/2009] There are 21 new articles in PLoS ONE today. As always, you should rate the articles, post notes and comments and send trackbacks when you blog about the papers. ...
Tumors take a blow [Spoonful of Medicine - Blog Posts - 06/11/2009] Cancer breakthroughs often get their first airing at the annual meeting of the American Society of Clinical Oncology. This year’s meeting was no exception. One ...
Comps reading & university scientist patent... [ScienceBlogs : Combined Feed - 06/06/2009] This post serves a few purposes. First, Bill Hooker questioned Crotty's assertion about the importance of patents to university researchers [*]. Bill also posted a ...
Building a better polio vaccine: Revisited [erv] [ScienceBlogs : Combined Feed - 04/15/2009] Last year I wrote about a cool paper, arguing for the creation of a new polio vaccine. Briefly, polio is an RNA virus, thus has an error-prone RNA-RNA polymerase, ...

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Polymerase